Following a childhood tragedy, Dewey Cox follows a long and winding road to music stardom. Dewey perseveres through changing musical styles, an addiction to nearly every drug known and bouts of uncontrollable rage.

You'd better watch out - Santa Claus Willie T. Soke is coming to town and he doesn't care if you've been naughty or nice. Wille's favorite holiday tradition is to fill his sacks with loot lifted from shopping malls across the country. But this year his plot gets derailed by a wisecracking store detective, a sexy bartender, and a kid who's convinced Willie is the real Santa Claus.

Advice columnist Dan Burns is an expert on relationships, but somehow struggles to succeed as a brother, a son and a single parent to three precocious daughters. Things get even more complicated when Dan finds out that the woman he falls in love with is actually his brother's new girlfriend.

Junior congressman Evan Baxter, whose wish is to "change the world" is heard by none other than God. When God appears with the perplexing request to build an ark, Evan is sure he is losing it.

Pete and Debbie are both about to turn 40, their kids hate each other, both of their businesses are failing, they're on the verge of losing their house, and their relationship is threatening to fall apart.

Famous and wealthy funnyman George Simmons doesn't give much thought to how he treats people until a doctor delivers stunning health news, forcing George to reevaluate his priorities with a little help from aspiring stand-up comic Ira.

A high school slacker who's rejected by every school he applies to opts to create his own institution of higher learning, the South Harmon Institute of Technology, on a rundown piece of property near his hometown.

When actress Sarah Marshall dumps aspiring musician Peter Bretter for rock star Aldous Snow, Peter's world comes crashing down. His best friend Brian suggests that Peter should get away from everything and to fly off to Hawaii to escape all his problems. After arriving in Hawaii and meeting the beautiful receptionist Rachel Jansen, Peter is shocked to see not only Aldous in Hawaii, but also Sarah.

Forced to move to a boring backwater town, a teenager embarks on affairs with a teacher and a stoner classmate.

Follows Andy, who needs to hook up with a hottie, pronto, because he hasn't had sex in... well, forever - and his luck isn't the only thing that's hard. His equally horny teenage roommates also need it superbad, and with the help of their nerdy pal, McAnalovin' and his fake I.D., they may tap more than just a keg.

Jenna is a pregnant, unhappily married waitress in the deep south. She meets a newcomer to her town and falls into an unlikely relationship as a last attempt at happiness.

Lifelong platonic friends Zack and Miri look to solve their respective cash-flow problems by making an adult film together. As the cameras roll, however, the duo begin to sense that they may have more feelings for each other than they previously thought.

Altruistic Jane finds herself facing her worst nightmare as her younger sister announces her engagement to the man Jane secretly adores.

After standing in as best man for his longtime friend Carl Petersen, Randy Dupree loses his job, becomes a barfly and attaches himself to the newlywed couple almost permanently -- as their houseguest. But the longer Dupree camps out on their couch, the closer he gets to Carl's bride, Molly, leaving the frustrated groom wondering when his pal will be moving out.

Two salesmen trash a company truck on an energy drink-fueled bender. Upon their arrest, the court gives them a choice: do hard time or spend 150 service hours with a mentorship program. After one day with the kids, however, jail doesn't look half bad.

Andy Stitzer has a pleasant life with a nice apartment and a job stamping invoices at an electronics store. But at age 40, there's one thing Andy hasn't done, and it's really bothering his sex-obsessed male co-workers: Andy is still a virgin. Determined to help Andy get laid, the guys make it their mission to de-virginize him. But it all seems hopeless until Andy meets small business owner Trish, a single mom.

Four couples, all friends, descend on a tropical island resort. Though one husband and wife are there to work on their marriage, the others just want to enjoy some fun in the sun. They soon find, however, that paradise comes at a price: Participation in couples therapy sessions is mandatory. What started out as a cut-rate vacation turns into an examination of the common problems many face.

A stoner and his dealer are forced to go on the run from the police after the pothead witnesses a cop commit a murder.

After a disastrous first date for caterer Holly and network sports director Messer, all they have in common is a dislike for each other and their love for their goddaughter Sophie. But when they suddenly become all Sophie has in this world, Holly and Messer must set their differences aside. Juggling careers and social calendars, they'll have to find common ground while living under the same roof.

Noah, is not your typical entertain-the-kids-no-matter-how-boring-it-is kind of sitter. He's reluctant to take a sitting gig; he'd rather, well, be doing anything else, especially if it involves slacking. When Noah is watching the neighbor's kid he gets a booty call from his girlfriend in the city. To hook up with her, Noah takes to the streets, but his urban adventure spins out of control as he finds himself on the run from a maniacal drug lord.