In the 18th season premiere, deputies Marc Taub and Joseph Ensminger of the Travis County, TX, Sheriff's Office question the residents of a home that has been burglarized and we learn that someone went into the house and completely trashed it. However, there is no sign of forced entry and nothing is missing from the property. The complainant and his friend, who appear inebriated, explain that they think they know who did it, and they believe it occurred because they would not smoke enough pot with him. Deputies take fingerprints from an article in the kitchen and advise the residents to be careful about whom they hang out with. In another segment, Corporal Bev Genevish, Officer James Presley and Lt. J.T. Strickland of the Gwinnett County, GA, Police Department investigate a call about a car hitting person riding a bike. At the scene, the driver's car has run off the road, and while the vehicle's windshield and hood are both damaged, the driver claims to have no memory of hitting anyone. As the investigation continues, a bloodied young boy stumbles toward officers, but the injury has impaired his memory and he cannot remember how it happened.

When Detectives Rudy Reynoso and Juan Gonzalez of the Las Vegas, NV, Metropolitan Police Department respond to a call regarding the discovery of a human skull in a local park, they conduct an extensive and cautious search. With the assistance of a forensic anthropologist, they find additional human bones and discarded clothing in the immediate area. After an exhaustive day, the remains are identified when the serial number from a cell phone is traced to a man who has been reported missing. Another segment featuring the Las Vegas, NV, Metropolitan Police Department follows Officer Christopher Curtis responding to a domestic disturbance call. At the scene, the officer interviews a woman who claims that her unstable ex-boyfriend tried to break into her apartment. The ex-boyfriend confirms the woman's account and eventually comes to the emotional realization that he loves a woman who does not feel the same.

Officers Judy Abercrombie and Diane King of the Gwinnett County, GA, Police Department respond to a domestic disturbance call from a local motel. As the officers approach the motel, they encounter a man and woman arguing in the parking lot. At the scene, the woman slaps the man after catching him a truck with another woman. Meanwhile, the emotional female is accused of running the man down and officers investigate further. Also featured is Deputy David Jones of the Maricopa County, AZ, Sheriff's Office, responding to a call where a male suspect has consumed large amounts of methamphetamine intravenously. While the incredibly altered, sweating and shaking suspect claims he's searching for a higher power, paramedics are called to the scene.

Stories include a fight call, police respond to a theft call as students attempt to steal a hotel's fake flamingo, and a prostitute is arrested during a traffic stop.

COPS in Lee County Florida. Stories include a domestic distrubance call where the husband fears for his life from his wife.

COPS from Las Vegas, Nevada. Stories include a simple car stop over a broken tail light yields a jar of meth.

When Detective Jason Lando of the Pittsburgh, PA, Bureau of Police investigates suspicious activity in a parking lot frequented by drug users and prostitutes, the parked driver claims to be waiting for her daughter. As the investigation continues, officers recognize the driver’s daughter as someone they encounter frequently. The shaky young girl is found with drug paraphernalia and the situation becomes very emotional as she is detained in front of her mother. On the other side of the country, Sgt. Tom Jenkins of the Las Vegas, NV, Metropolitan Police Department stops a young female behaving suspiciously on the legendary Las Vegas strip. After the female suspect lies to Sgt. Jenkins, she eventually breaks down and admits to working the streets. Another segment features Officer Derek Bishop of the Spokane, WA, Police Department, responding to a call where a female suspect claims to be hitchhiking. Although she was ticketed several weeks before for prostitution, she maintains her innocence. When officers begin to question her credibility, some arresting surprises surface and the suspect attempts to bargain with officers.

From Las Vegas, Nv. Stories include a call for assistance at an apartment complex in which an uncooperative supect is dealt with.

Stories from Ft. Myers, Fl.. Las Vegas and Lee County, Florida. Police are dispatched to a call from a person who was approached by a man with a gun that claimed he had used it in robbing a bank.

From Ft. Myers, Fl., Las Vegas, Nv., and Fresno, Ca. Stories include Police setting out to apprehend drug dealers by using a taxi cab.

From Las Vegas, Nv, Travis County, Texas, and Atlanta, Ga. Police respond to a call that involves a man who has detained by force a suspect caught in the act of vandalism. Other stories include a domestic disturbance in Texas and a stolen car in Georgia.

From Gwinnett County, GA; Las Vegas, NV; and Travis County, TX. Stories include a fight in progress call; a family dispute; and a car stop reveals a large quantity of marijuana.

Stories are from Gwinnett, County, Ga, Las Vegas, Nv, Travis County, Tx and Atlanta, Ga. A backpack full of drugs is found during the arrest of suspects in an area known for heroin deals.

In Las Vegas, Nevada, officers respond to a disturbance call where a customer was threatened by a disturbed man.

When Det. Joe Lewis and Sgt. Jason Snyder of the Pittsburgh, PA, Bureau of Police stop a vehicle, the driver immediately speeds off and a chase ensues. Once apprehended, the suspect tells the undercover officers he was afraid of being sent to jail for having a small amount of “weed” in his pocket. However, as the investigation continues, we learn that the suspect has been convicted of a felony. Another segment features Officers Derrick Pendergrass and Zach Fuller of the Chattanooga, TN, Police Department stopping a vehicle for having tags that don’t match the car they are allegedly registered to, and for failure to maintain lanes. The driver appears very nervous and immediately hands the officers an empty plastic bag. This intoxicated suspect admits that beer somehow spilled in the front seat of his car

When Officer Alan Edwards and K-9 Officer Craig Hamilton of the Spokane, WA, Police Department respond to a call regarding a male who has been eluding police and burglarizing homes, the suspect is initially found hiding on the roof of a dwelling. When the suspect scrambles around, there is a short negotiation after officers announce they have a police dog. Another segment features Officers Michael Joiner and Kevin Trussell of the Chattanooga, TN, Police Department as they respond to a call from a woman who wants to know if her husband is manufacturing meth in their home.

Detectives Tony Moreno and Brian Nicholas of the Pittsburgh, PA, Bureau of Police approach two individuals they suspect are involved in an illegal "hand to hand" drug transaction. When a suspect turns and attempts to dispose of a handgun, the detectives arrest both individuals without any hesitation. After it is discovered that the detained suspect's mouth is filled with crack, he dramatically laments his situation, calling himself a "loser." In a disturbing and shocking segment, Officers Jack Carson and Sally Jones of the Anchorage, AK, Police Department respond to bizarre call about a male suspect attempting to sell or trade a juvenile female for crack cocaine.

When Officers Jeremy Daniel and Jerry Anderson of the Spokane, WA, Police Department respond to a call about a male suspect, armed with a knife, who is apparently on drugs and has threatened to kill at least one person, they are forced to have a physical altercation with the enraged man. The episode also features Officer Darrell Evans of the Anchorage, AK, Police Department investigating a report of two men who earlier assaulted a male victim and told their dog to attack.

Officer Derrick Pendergrass of the Chattanooga, TN, Police Department responds to a call where a bleeding woman has passed out on the sidewalk. At the scene, it becomes obvious that the woman is extremely intoxicated and cannot recall anything. When the woman refuses to sit still, she attempts to bite Officer Pendergrass. In another segment, when Deputy Heather Savage of the Martin County, FL, Sheriff's Office spots a woman walking down a strip of highway known for heavy drug and prostitution activity, she stops her for questioning. The woman claims that although she has been arrested in the past for prostitution-related crimes, she was only on the way to cash her welfare check. A routine search of the woman's possessions turns up crack cocaine, and after being detained, the woman reveals that she has a crack pipe in the crotch of her underpants.

Officer William Hutchinson of the Palm Springs, CA, Police Department joins a high-speed chase that ends abruptly when the driver crashes into a fence. As the chase concludes, a naked male driver jumps the fence and takes off on foot while officers question a tearful female passenger with torn clothes. The driver is quickly apprehended and brought back to the scene in a police car, where the investigation proceeds. Also featured from the Palm Springs Police Department is Officer William Hutchinson, checking out a vehicle parked outside an apartment complex. As Hutchinson approaches the car, he observes two men seated inside. When the driver opens his door, a cloud of marijuana smoke begins to billow out, prompting the officer to remove the men from the car.

After Sgt. Jason Snyder and Detective Phil Mecurio of the Pittsburgh, PA, Bureau of Police notice a bulge in the pants of two males, a foot chase ensues and eventually Sgt. Snyder discovers the bulge is a gun, which the suspect claims is for protection. Another segment features Deputy Jason Howard of the Martin County, FL, Sheriff's Office, responding to a call where a man reported that a woman was causing a disturbance at his private residence and refused to leave. Although the complainant manages to utter that she tore down part of his fence, she is inebriated and incoherent and denies any wrongdoing.

When Corporal Jim Muzatko of the Spokane, WA, Police Department engages in a high-speed pursuit of a stolen truck, the desperate driver turns onto a deserted dirt road and the officer executes the "pit maneuver" to stop the pursuit. Also featured is Officer William Hutchinson of the Palm Springs, CA, Police Department, patrolling an area known for a high volume of prostitution and drug activity. He notices a parked car where three males, two of them dressed in full drag, are questioned.

When Officer William Hutchinson of the Palm Springs, CA, Police Department responds to a call regarding a man who allegedly attempted to steal a truck in the parking lot of a strip mall, the hostile suspect tells police that he had been drinking and believed he was in his own vehicle. Another segment features Officer Mike Reddy and Officer Jerry Kabala of the Pittsburgh, PA, Bureau of Police, pulling over a vehicle after it is seen leaving a lot frequented by heroin users. The female driver and male passenger tell the officers they were just looking for the driver's mother. An investigation reveals a different story.